Research Projects

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Maine INBRE supports the interrelated research projects of between six to nine INBRE faculty each year, enabling these more junior scientists to seek independent funding during the grant period. The INBRE program also supports pilot research projects for teaching-focused faculty and their students. Each project applies the strategies of comparative functional genomics—where scientists study the role and function of genes in a variety of different organisms—to biomedical issues in physiology, toxicology, and molecular and cellular developmental biology. Current project leaders are listed below.

Current Funding Opportunity Announcement (FOA) – Opens 11/13/2023; Applications Due 2/2/2024; Potential Start Date: 5/1/2024

Maine INBRE also participates in the NorthEast Cyberinfrastructure Consortium, which is a regional effort to facilitate cyber-enabled collaborative research among the Northeast Regional IDeA States: Delaware, New Hampshire, Maine, Rhode Island, and Vermont. The NEBC has worked collaboratively to characterize the genome of the little skate, Leucoraja erinacea, in the Skate Genome Project.

Current Investigator Research

Catalysis of early metabolic pathways as a form of hereditary during a possible emergence of life from hydrothermal vents

Catalysis of early metabolic pathways as a form of hereditary during a possible emergence of life from hydrothermal vents

Investigator: Reuben Hudson, Ph.D., College of the Atlantic Project Summary Carbon fixation to simple organic building blocks, and the subsequent increases in molecular complexity underpins countless universal cellular processes. This study...
Determining the role of calcium on the mitochondrial unfolded protein response

Determining the role of calcium on the mitochondrial unfolded protein response

Investigator: Suzanne Angeli, Ph.D., University of Maine Project Summary The opening of the mitochondrial permeability transition pore (mPTP) is associated is associated with aging and numerous age-related diseases. This proposal examines the...
Functional role of protein secretion systems shared among Paraburkholderia symbionts of social amoebas

Functional role of protein secretion systems shared among Paraburkholderia symbionts of social amoebas

Investigator: Suegene Noh, Ph.D., Colby College Project Summary Our goal is to better understand how and why fitness outcomes differ among hosts when they encounter the same microbial symbiont in social groups. The amoeba Dictyostelium discoideum...
Identification of neural and epigenetic biomarkers for affective dysfunction following early adversity

Identification of neural and epigenetic biomarkers for affective dysfunction following early adversity

Investigator: Jennifer Honeycutt, PhD, Bowdoin College An individual’s early life environment plays a central role in shaping developmental trajectories, and therefore confers substantial influence on later-life physical and mental health outcomes. A...
Understanding the mechanisms of MMS21 in genome instability through mutations in Saccaramyces cerevisiae and human

Understanding the mechanisms of MMS21 in genome instability through mutations in Saccaramyces cerevisiae and human

Investigator: Yee Mon Thu, PhD, Colby College Genome instability describes a condition in which the accuracy of genetic information or structural integrity of the genome is compromised. Under such a condition, the DNA molecule may be chemically...

Current Teaching Faculty Research

A functional analysis of RnaseT2 in Yeast

A functional analysis of RnaseT2 in Yeast

Investigator: Jennifer Garcia, Ph.D., University of New England Project Summary Expression of human Rnase T2 enzymes has been shown to restrict tumor growth. In line with this, our work shows that the S. cerevisiae Rnase T2 enzyme, Rny1, slows...
Evolution of gene regulation within and between species of Drosophila

Evolution of gene regulation within and between species of Drosophila

Teaching Faculty: Michael Palopoli, PhD, Bowdoin College Our lab studies natural variation in gene expression. In particular, we are examining the extent to which gene regulation varies within and among species of fruit flies by quantifying variation...
Influence of colonization regime, time since establishment, and site-specific variation on patterns of selection, genes under selection, and rapid evolution in distinct swift fox (Vulpes velox) populations

Influence of colonization regime, time since establishment, and site-specific variation on patterns of selection, genes under selection, and rapid evolution in distinct swift fox (Vulpes velox) populations

  Teaching Faculty: Donelle (Doni) Schwalm, PhD, University of Maine at Farmington The process of colonization and recolonization is central to species persistence, in particular during periods of intense environmental change. Myriad factors ...
Unfolded Protein Responses in Toll-Like Receptor-Mediated Antiviral Inflammation

Unfolded Protein Responses in Toll-Like Receptor-Mediated Antiviral Inflammation

 Teaching Faculty: Con Sullivan, Ph.D., University of Maine at Augusta Viral diseases are consistently among the most pervasive healthcare burdens in the world. A key feature of viral diseases like COVID-19 and influenza A that contributes their mortality ...

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