Research Projects

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Maine INBRE supports the research projects of between six to nine INBRE faculty each year, enabling these more junior scientists to seek independent funding during the grant period. The INBRE program also supports pilot research projects for teaching-focused faculty and their students. Projects study a range of biomedical issues in physiology, toxicology, and molecular and cellular developmental biology, among other areas of focus. Current project leaders are listed below.

Funding Opportunity Announcement (FOA) – Opens 11/13/2023; Applications Due 2/2/2024; Potential Start Date: 5/1/2024

Maine INBRE also participates in the NorthEast Cyberinfrastructure Consortium, which is a regional effort to facilitate cyber-enabled collaborative research among the Northeast Regional IDeA States: Delaware, New Hampshire, Maine, Rhode Island, and Vermont. The NEBC has worked collaboratively to characterize the genome of the little skate, Leucoraja erinacea, in the Skate Genome Project.

Current Research Projects

Catalysis of early metabolic pathways as a form of hereditary during a possible emergence of life from hydrothermal vents

Catalysis of early metabolic pathways as a form of hereditary during a possible emergence of life from hydrothermal vents

Investigator: Reuben Hudson, Ph.D., College of the Atlantic Project Summary Carbon fixation to simple organic building blocks, and the subsequent increases in molecular complexity underpins countless universal cellular processes. This study...
Determining the role of calcium on the mitochondrial unfolded protein response

Determining the role of calcium on the mitochondrial unfolded protein response

Investigator: Suzanne Angeli, Ph.D., University of Maine Project Summary The opening of the mitochondrial permeability transition pore (mPTP) is associated is associated with aging and numerous age-related diseases. This proposal examines the...
Identification of neural and epigenetic biomarkers for affective dysfunction following early adversity

Identification of neural and epigenetic biomarkers for affective dysfunction following early adversity

Investigator: Jennifer Honeycutt, PhD, Bowdoin College An individual’s early life environment plays a central role in shaping developmental trajectories, and therefore confers substantial influence on later-life physical and mental health outcomes. A...
Understanding the mechanisms of MMS21 in genome instability through mutations in Saccaramyces cerevisiae and human

Understanding the mechanisms of MMS21 in genome instability through mutations in Saccaramyces cerevisiae and human

Investigator: Yee Mon Thu, PhD, Colby College Genome instability describes a condition in which the accuracy of genetic information or structural integrity of the genome is compromised. Under such a condition, the DNA molecule may be chemically...
Unveiling the BAR “code” of srGAPs through phospholipid targeting, curvature preferences and actin regulation in the control of cellular protrusions

Unveiling the BAR “code” of srGAPs through phospholipid targeting, curvature preferences and actin regulation in the control of cellular protrusions

Investigator: Michael Henderson, Ph.D., Bowdoin College Project Summary Cell shape changes, including the formation of highly curved finger-like filopodia, mediate processes like migration, tissue closure, and synaptic maturation. The mechanisms...

Current Pilot Projects

A functional analysis of RnaseT2 in Yeast

A functional analysis of RnaseT2 in Yeast

Investigator: Jennifer Garcia, Ph.D., University of New England Project Summary Expression of human Rnase T2 enzymes has been shown to restrict tumor growth. In line with this, our work shows that the S. cerevisiae Rnase T2 enzyme, Rny1, slows...

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