Research Projects

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Maine INBRE has directly supported 64 faculty research projects since its inception, including 54 early-career scientists, 33% of whom have “graduated” from the INBRE program by achieving independent funding to support their research.

How to Acknowledge INBRE Support

Each year, INBRE supports research and pilot projects conducted by faculty throughout the state of Maine, enabling early career scientists to seek independent funding for their research, and teaching-focused faculty to provide robust research opportunities for their students.  Projects study a range of biomedical issues in physiology, toxicology, and molecular and cellular developmental biology, among other areas of focus.

A Funding Opportunity Announcement (FOA) to apply for research or pilot project funding is released annually.

Maine INBRE also participates in the NorthEast Cyberinfrastructure Consortium, which is a regional effort to facilitate cyber-enabled collaborative research among the Northeast Regional IDeA States: Delaware, New Hampshire, Maine, Rhode Island, and Vermont. The NEBC has worked collaboratively to characterize the genome of the little skate, Leucoraja erinacea, in the Skate Genome Project.

Current Research Projects

Catalysis of early metabolic pathways as a form of hereditary during a possible emergence of life from hydrothermal vents

Catalysis of early metabolic pathways as a form of hereditary during a possible emergence of life from hydrothermal vents

Investigator: Reuben Hudson, Ph.D., Colby College Project Summary Carbon fixation to simple organic building blocks, and the subsequent increases in molecular complexity underpins countless universal cellular processes. This study aims to explore...
Investigating the Kingella kingae Type IV Pili Response to Host-Derived Stimuli

Investigating the Kingella kingae Type IV Pili Response to Host-Derived Stimuli

Investigator: Ifrah Shahi, Ph.D., Bates College Project Summary Kingella kingae is a Gram-negative bacterial pathogen and a leading cause of osteomyelitis and septic arthritis in children. K. kingae expresses surface fibers called...
Unveiling the BAR “code” of srGAPs through phospholipid targeting, curvature preferences and actin regulation in the control of cellular protrusions

Unveiling the BAR “code” of srGAPs through phospholipid targeting, curvature preferences and actin regulation in the control of cellular protrusions

Investigator: Michael Henderson, Ph.D., Bowdoin College Project Summary Cell shape changes, including the formation of highly curved finger-like filopodia, mediate processes like migration, tissue closure, and synaptic maturation. The mechanisms...

Current Pilot Projects

Characterizing Human-Disease Mutations in the Essential RNA Exosome with Budding Yeast

Characterizing Human-Disease Mutations in the Essential RNA Exosome with Budding Yeast

  Investigator: Maria Sterrett, Ph.D., Bowdoin College RNA molecules encode proteins and regulate other essential molecules in our cells. The RNA content of a cell is regulated in part by evolutionarily conserved RNA decay machines such as ...
Integrating computational and neural methods to identify explore-exploit tradeoffs in memory search

Integrating computational and neural methods to identify explore-exploit tradeoffs in memory search

Investigator: Abhilasha Kumar, Ph.D., Bowdoin College Project Summary Retrieval of concepts from semantic memory involves interactions between several brain regions and a complex interplay of lexical sources. Recent work with the verbal...
Polyphenic muscle development and histolysis as a novel model of sarcopenia

Polyphenic muscle development and histolysis as a novel model of sarcopenia

Investigator: David Angelini, Ph.D., Colby College Project Summary Sarcopenia, or age-related muscle loss, is poorly understood at the genetic level. This study uses soapberry bugs as a model for muscle plasticity, leveraging their nutritionally...

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