Investigator: Suzanne Angeli, Ph.D., University of Maine
Project Summary
The opening of the mitochondrial permeability transition pore (mPTP) is associated is associated with aging and numerous age-related diseases. This proposal examines the mechanistic interaction of the mPTP and the mitochondrial unfolded protein response (UPRmt). We will examine the role of calcium signaling and its relationship to the mPTP/UPRmt nexus, which is of high biomedical importance.
Angeli Lab University of Maine