A functional analysis of RnaseT2 in Yeast

Investigator: Jennifer Garcia, Ph.D., University of New England

Project Summary

Expression of human Rnase T2 enzymes has been shown to restrict tumor growth. In line with this, our work shows that the S. cerevisiae Rnase T2 enzyme, Rny1, slows the growth of dividing cells. To test if this extends to other Rnase T2 enzymes, we will test which conserved domains of Rny1 are needed to regulate growth. Our work also suggests that Rny1 may contribute to phosphate metabolism, which is intimately linked to cell cycle start in yeast. We will examine this link to deciper how Rny1 can alter growth.

Garcia Lab at the University of New England