Catalysis of early metabolic pathways as a form of hereditary during a possible emergence of life from hydrothermal vents
Investigator: Reuben Hudson, Ph.D., College of the Atlantic
Project Summary
Carbon fixation to simple organic building blocks, and the subsequent increases in molecular complexity underpins countless universal cellular processes. This study...
Determining the role of calcium on the mitochondrial unfolded protein response
Investigator: Suzanne Angeli, Ph.D., University of Maine
Project Summary
The opening of the mitochondrial permeability transition pore (mPTP) is associated is associated with aging and numerous age-related diseases. This proposal examines the...
Functional role of protein secretion systems shared among Paraburkholderia symbionts of social amoebas
Investigator: Suegene Noh, Ph.D., Colby College
Project Summary
Our goal is to better understand how and why fitness outcomes differ among hosts when they encounter the same microbial symbiont in social groups. The amoeba Dictyostelium discoideum...
Identification of neural and epigenetic biomarkers for affective dysfunction following early adversity
Investigator: Jennifer Honeycutt, PhD, Bowdoin College
An individual’s early life environment plays a central role in shaping developmental trajectories, and therefore confers substantial influence on later-life physical and mental health outcomes. A...
Understanding the mechanisms of MMS21 in genome instability through mutations in Saccaramyces cerevisiae and human
Investigator: Yee Mon Thu, PhD, Colby College
Genome instability describes a condition in which the accuracy of genetic information or structural integrity of the genome is compromised. Under such a condition, the DNA molecule may be chemically...